Few descendants from this family live in San Miguel, as only Don Ezequiel Lopez Escobedo had children. The eldest of his grandchildren is Marcela Andre Lopez, an international teacher and designer of jewel garlands now in residence in the historic district in one of Don Ezequiel Lopez Escobedo's homes. Sr. Ezequiel Lopez Basurto, son of Don Ezequiel Lopez Escobedo, has presided over many works by the Rotary Club.

In the early 20th Century, the family fortune of the Lopez Escobedo brothers and sisters was largely donated to schools for girls, convents for nuns, or lost to older distant relatives and people helped by the family who falsified papers or discovered hidden treasure after Don Ezequiel's sudden stroke and death. The impoverished barkeeper's assistant who found Don Ezequiel's property deeds and gold kept the find from Don Ezequiel's widow and five children who suffered hardships as orphans. The barkeeper's assistant had leased the store at Calle Relox and San Francisco Street from Don Ezequiel's widow and in the abundant inventory found more than could have been imagined.

Peruvian artist Felipe Cossio del Pomar established in 1938 San Miguel’s first art school, the Escuela Universitaria de Bellas Artes, located in the former convent that houses the present Bellas Artes. He offered the position of Art Director to American artist and writer Stirling Dickinson. Dickinson taught Spanish, botany and landscape painting, as well as taking students on field trips as part of his "Aspects of Mexico" course.

According to author John Virtue, who has written a new biography of Dickinson, "The Model American Abroad", Dickinson's impact on San Miguel was manifested in many ways. He had arrived in San Miguel before daybreak on February 7, 1937. At the Jardín, Stirling looked up at the spires of the Parroquia poking through the mist. "My God, what a sight!" he said to himself. "I’m going to stay here." Besides his teaching, in 1942, after just five years in San Miguel, Stirling had been named a Favored Adopted Son, the only time the mayor’s office has so honored an American resident. Two years later, he was honored by the governor for his work with young Mexicans, a result of his founding the baseball team. So huge was his impact on San Miguel just through helping generation after generation of his baseball players, that the eventual baseball field he helped build and finance, was named Campo Stirling Dickinson. He also began what was probably the largest private orchid collection in Mexico, a lifelong interest that was highlighted by the discovery of one new orchid, Encyclia dickinsoniana—and having a second named after him in recognition of his work: Cypripedium dickinsonianum.